تفاعل #2314283

معادلة التفاعل

HCl

acid chloride

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetyl chloride

anisole

→

4-Methoxyphenyl (4-(4-methyl-3-pentenyl)-3-cyclohexenyl)methyl ketone

المذيبات

dichloromethane

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled in an ice/ethanol bath
2. 2
   workup.STIRRINGstirred for 30 minutes
3. 3
   استخلاصThe aqueous layer is extracted with dichloromethane
4. 4
   غسيلthe combined organic layers are sequentially washed with water, sodium bicarbonate, and water
5. 5
   تجفيفdried over magnesium sulfate
6. 6
   تركيزThe solution is concentrated in vacuo

الإجراء التجريبي

A solution of acid chloride 2C (R=4-Methyl-3-pentenyl) (10 g) in anhydrous dichloromethane (100 mL) is added dropwise to a mixture of ferric chloride (7.8 g) and anisole 2D (4.5 g) in dichloromethane (175 mL), cooled in an ice/ethanol bath. The resulting mixture is gradually warmed to room temperature and stirred overnight. The mixture is poured into 25% HCl (150 mL) and stirred for 30 minutes. The aqueous layer is extracted with dichloromethane, and the combined organic layers are sequentially washed with water, sodium bicarbonate, and water, then dried over magnesium sulfate. The solution is concentrated in vacuo.

المصدر