تفاعل #2314281

معادلة التفاعل

hydrochloric acid

sodium hydroxide

nitrile

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

water

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetic acid

المذيبات

hydrogen peroxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux overnight
2. 2
   استخلاصThe acid product is extracted with ethyl acetate
3. 3
   غسيلthe combined organic layers are washed with brine
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   تركيزThe solution is concentrated in vacuo

الإجراء التجريبي

To a solution of sodium hydroxide (10.5 g) in water (150 mL) and 30% hydrogen peroxide (50 mL) is added the nitrile 2A (R=4-Methyl-3-pentenyl) (10 g). The reaction mixture is stirred at reflux overnight. The reaction is then cooled to room temperature, and poured into a mixture of ice (30 g) and hydrochloric acid (22 mL). The acid product is extracted with ethyl acetate, and the combined organic layers are washed with brine and dried over magnesium sulfate. The solution is concentrated in vacuo.

المصدر