تفاعل #2314280

معادلة التفاعل

water

tosylate

potassium cyanide

→

(4-(4-Methyl-3-pentenyl)-3-cyclohexenyl)acetonitrile

المذيبات

dimethylsulfoxide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe reaction mixture is cooled to room temperature
2. 2
   استخلاصextracted with hexane
3. 3
   تجفيفThe combined organic layers are dried over magnesium sulfate
4. 4
   تركيزthe solution is concentrated in vacuo

الإجراء التجريبي

To a solution of tosylate 1H (R=4-Methyl-3-pentenyl) (20 g) in dimethylsulfoxide (178 mL) is added potassium cyanide (19.4 g). The reaction mixture is heated to 100° C., and the reaction mixture is stirred at that temperature for three hours. The reaction mixture is cooled to room temperature, added to water (300 mL), and extracted with hexane. The combined organic layers are dried over magnesium sulfate and the solution is concentrated in vacuo.

المصدر