تفاعل #2307967

ord-84004a01edaa4803a8018f5eaee77331

معادلة التفاعل

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid
→
CCCCCCCCCCCCCCCCCC(=O)O.CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine Stearic Acid

المتفاعلات

CO[C@@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1Cc4ccc(O)c5c4[C@@]3(CCN1CC1CC1)[C@H]2O5
Buprenorphine
CCCCCCCCCCCCCCCCCC(=O)O
stearic acid

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    ترشيحsieved through a 120-mesh screen
  2. 2
    أخرىto obtain particles

الإجراء التجريبي

Equal amounts of Buprenorphine particles (prepared as described in Example 4) above) and stearic acid (prepared as described in Example 3) were blended and ground. The ground material was compressed in a 13-mm round die, with a force of 5,000 pounds for 5 minutes. Compressed tablets were ground and sieved through a 120-mesh screen followed by a 230-mesh screen to obtain particles having a size range between 63-125 microns.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07368126B2uspto-grants-2008_05