تفاعل #2307966

معادلة التفاعل

Bupivacaine hydrochloride

sodium hydroxide

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Bupivacaine

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىto precipitate the Bupivacaine base
2. 2
   ترشيحThe precipitated product was filtered
3. 3
   غسيلfurther washed with DI water at least three times
4. 4
   أخرىThe precipitated product was dried at ca. 40° C. in vacuum for 24 hours

الإجراء التجريبي

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in deionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixture was adjusted to 10 to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

المصدر