تفاعل #2304293

معادلة التفاعل

4-benzyloxybromobenzene

4-(trifluoromethoxy)benzeneboronic acid

sodium carbonate

ethylene glycol dimethyl ether

→

4-benzyloxy-4′-(trifluoromethoxy)biphenyl

المردود 35.9%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe reaction mixture was extracted with toluene
2. 2
   تجفيفthe organic layer was dried with anhydrous magnesium sulfate
3. 3
   أخرىThe solvent was evaporated away
4. 4
   أخرىthe resulting residue was purified through silica gel chromatography (elution solvent: heptane/toluene=7/3)
5. 5
   أخرىrecrystallized from heptane

الإجراء التجريبي

A reaction mixture comprising 6.7 g of 4-benzyloxybromobenzene, 5.0 g of 4-(trifluoromethoxy)benzeneboronic acid, 0.3 g of tetrakis(triphenylphosphine)palladium(0), 5.1 g of sodium carbonate, 100 ml of ethylene glycol dimethyl ether and 20 ml of pure water was refluxed for 5 hours. The reaction mixture was extracted with toluene, and the organic layer was dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel chromatography (elution solvent: heptane/toluene=7/3) and recrystallized from heptane, and 3.0 g of 4-benzyloxy-4′-(trifluoromethoxy)biphenyl was obtained. m.p.: 136-137.2° C.

المصدر