تفاعل #2304287

معادلة التفاعل

3-[(6-bromohexyloxy)methyl]-3-methyloxetane

ethyl 4-hydroxybenzoate

potassium carbonate

dimethylformamide

→

ethyl 4-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]benzoate

المردود 80.6%

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   استخلاصThis was extracted with ethyl acetate
2. 2
   غسيلthe organic layer was washed with aqueous 2 N-sodium hydroxide solution and water in that order
3. 3
   تجفيفdried with anhydrous magnesium sulfate
4. 4
   أخرىThe solvent was evaporated away
5. 5
   أخرىthe resulting residue was purified through silica gel chromatography (elution solvent:toluene/ethyl acetate=8/2)

الإجراء التجريبي

A reaction mixture comprising 84 g of 3-[(6-bromohexyloxy)methyl]-3-methyloxetane, 50 g of ethyl 4-hydroxybenzoate, 50 g of potassium carbonate and 600 ml of dimethylformamide was stirred at 90° C. for 4 hours. Water was added to the reaction mixture and the reaction was stopped. This was extracted with ethyl acetate, and the organic layer was washed with aqueous 2 N-sodium hydroxide solution and water in that order, and then dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel chromatography (elution solvent:toluene/ethyl acetate=8/2), and 85 g of ethyl 4-[6-(3-methyloxetan-3-ylmethoxy)hexyloxy]benzoate was obtained.

المصدر