تفاعل #2303

معادلة التفاعل

4-(piperazin-1-yl)anisole

4-chloropyridine hydrochloride

ammonia

→

4-[4-(4-pyridyl)-piperazin-1-yl]anisole

المردود 31.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated at 160°-170° C. (bath temperature) for 7 minutes
2. 2
   أخرىThe solid obtained
3. 3
   درجة الحرارةon cooling
4. 4
   استخلاصThe solid precipitate was extracted into ethyl acetate
5. 5
   استخلاصthe organic extract
6. 6
   غسيلwashed with water
7. 7
   ترشيحfiltered through phase
8. 8
   أخرىseparating paper (Whatman 1PS)
9. 9
   أخرىevaporated
10. 10
    أخرىThe residue was recrystallised from ethanol

الإجراء التجريبي

4-(piperazin-1-yl)anisole (4.24 g) and 4-chloropyridine hydrochloride (3.35 g) were intimately mixed and heated at 160°-170° C. (bath temperature) for 7 minutes. The solid obtained on cooling was dissolved in water (75 ml) and the solution basified with aqueous ammonia. The solid precipitate was extracted into ethyl acetate and the organic extract washed with water, filtered through phase separating paper (Whatman 1PS) and evaporated. The residue was recrystallised from ethanol to give 4-[4-(4-pyridyl)-piperazin-1-yl]anisole (1.84 g) as a solid: m.p. 165°-167° C.; NMR (CDCl3) δ8.3(2H,d); 6.86(4H,m); 6.71(2H,d); 3.78(3H,s); 3.46(4H,m); 3.2(4H,m).

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