تفاعل #2302152

معادلة التفاعل

water

sodium bicarbonate

4-chloromethyl-2-(thiophen-3-yl)-1,3-thiazole

2-amino-4-[4-(2-methoxyethoxy)phenyl]-6-sulphanyl-pyridine-3,5-dicarbonitrile

→

2-Amino-4-[4-(2-methoxyethoxy)phenyl]-6-[(2-(thiophen-3-yl)-1,3-thiazol-4-yl) -methylsulphanyl]pyridine-3,5-dicarbonitrile

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe precipitate is filtered off with suction
2. 2
   غسيلwashed with ethanol and diethyl ether
3. 3
   أخرىdried at 40° C. under reduced pressure

الإجراء التجريبي

100 mg (0.31 mmol) of 2-amino-4-[4-(2-methoxyethoxy)phenyl]-6-sulphanyl-pyridine-3,5-dicarbonitrile are dissolved in 1 ml of DMF. 103 mg (1.23 mmol) of sodium bicarbonate and 96.4 mg (0.46 mmol) of 4-chloromethyl-2-(thiophen-3-yl)-1,3-thiazole are then added. The suspension is shaken at RT overnight, and water is added. The precipitate is filtered off with suction, washed with ethanol and diethyl ether and dried at 40° C. under reduced pressure. This gives 141 mg (82% of theory) of product.

المصدر