تفاعل #2300012

معادلة التفاعل

tridecane

6-methoxy-1,2,3,4-tetrahydronaphthalene

bitoluene

6-methoxy-1,2,3,4-tetrahydronaphthalene

PCy3

→

6-(4-methylphenyl)-1,2,3,4-tetrahydronaphthalene

المردود 76.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىIn a reaction flask was placed
2. 2
   أخرىA sample was withdrawn
3. 3
   أخرىquenched with an aqueous sodium citrate solution (1 M)
4. 4
   استخلاصThe aqueous solution was extracted with ethyl acetate

الإجراء التجريبي

In a reaction flask was placed NiCl2(PCy3)2 (61.2 mg, 0.0886 mmol), PCy3 (49.0 mg, 0.175 mmol), tridecane (255 mg, 1.386 mmol, as an internal standard), and 6-methoxy-1,2,3,4-tetrahydronaphthalene (273 mg, 1.683 mmol). The Grignard reagent (1 M in THF, 5.0 mmol) was added to this mixture under a nitrogen atmosphere at room temperature. The resulting solution was warmed to 60° C. for 15 hours. A sample was withdrawn and quenched with an aqueous sodium citrate solution (1 M). The aqueous solution was extracted with ethyl acetate. GC analysis of the organic phase showed the presence of 6-(4-methylphenyl)-1,2,3,4-tetrahydronaphthalene (1.272 mmol, 76% yield), bitoluene (0.50 mmol), and 6-methoxy-1,2,3,4-tetrahydronaphthalene (0.357 mmol) in the reaction mixture.

المصدر