تفاعل #2297250

معادلة التفاعل

ammonia

hydrochloric acid

Sodium borohydride

ethyl 3-(2-cyanoethenyl)-5-(3-pyridylmethyl)cinnamate

→

title compound

المردود 40.2%

Ethyl 3-[3-(3-amino-1-propyl)-5-(3-pyridylmethyl)phenyl]propanoate

المردود 40.2%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGstirred for a further 10 minutes
2. 2
   ترشيحfiltered
3. 3
   غسيلThe filtered material was washed with ethyl acetate
4. 4
   غسيلthe combined filtrate and washings washed with water
5. 5
   استخلاصthe combined aqueous washings then extracted three times with dichloromethane
6. 6
   تجفيفdried (MgSO4)
7. 7
   أخرىevaporated under vacuum
8. 8
   أخرىto give a gum, which
9. 9
   أخرىwas chromatographed on silica gel
10. 10
    غسيلThe column was eluted with a methanol in dichloromethane elution gradient (1% to 5% methanol)
11. 11
    غسيلmethanol:aqueous ammonia (SG 0.880) elution gradient (94:5:1 to 90:9:1)
12. 12
    أخرىevaporated under vacuum

الإجراء التجريبي

Sodium borohydride (2.30 g) was added portionwise with vigorous stirring to a solution of ethyl 3-(2-cyanoethenyl)-5-(3-pyridylmethyl)cinnamate (Preparation 19; 2.0 g) and cobalt(II) chloride hexahydrate (4.48 g) in ethanol (150 ml) at 0° C. The mixture was stirred for 2 hours, carefully acidified to pH 2 with concentrated hydrochloric acid, stirred for a further 10 minutes, basified with concentrated aqueous ammonia solution (SG 0.880) and then filtered. The filtered material was washed with ethyl acetate, the combined filtrate and washings washed with water, and the combined aqueous washings then extracted three times with dichloromethane. The organic extracts were combined, dried (MgSO4) and evaporated under vacuum to give a gum, which was chromatographed on silica gel. The column was eluted with a methanol in dichloromethane elution gradient (1% to 5% methanol), followed by a dichloromethane: methanol:aqueous ammonia (SG 0.880) elution gradient (94:5:1 to 90:9:1). The product fractions were combined and evaporated under vacuum to give the title compound as a gum (0.825 g); Rf 0.25 (SS 2); δ (CDCl3): 1.20(3H,t,J=7.1 Hz), 1.70-1.77(4H,m), 2.54-2.60(4H,m), 2.70(2H,t,J=7.0 Hz), 2.87(2H,t,J=7.8 Hz), 3.90(2H,s), 4.09(2H,q,J=7.1 Hz), 6.83(2H,s), 6.88(1H,s), 7.18-7.22(1H,m), 7.43-7.46(1H,m), 8.43-8.48(2H,m).

المصدر