تفاعل #2295972

معادلة التفاعل

methyl 5-bromo-2-chloro-3-(cyclopentylamino)benzoate

cesium carbonate

methyl iodide

→

methyl 5-bromo-2-chloro-3-(cyclopentyl(methyl)amino)benzoate

المردود 61.2%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةOn completion, the reaction mixture was cooled to room temperature
2. 2
   ترشيحfiltered
3. 3
   غسيلThe residue was washed with ethyl acetate
4. 4
   تركيزthe filtrate was concentrated
5. 5
   أخرىpurified by column chromatography

الإجراء التجريبي

To a stirred solution of methyl 5-bromo-2-chloro-3-(cyclopentylamino)benzoate (0.550 g, 1.65 mmol) in acetonitrile (20 mL) was added cesium carbonate (1.08 g, 3.31 mmol) and methyl iodide (1.17 g, 8.25 mmol). The reaction mixture was heated at 80° C. for 12 h. On completion, the reaction mixture was cooled to room temperature and filtered. The residue was washed with ethyl acetate and the filtrate was concentrated and purified by column chromatography to afford methyl 5-bromo-2-chloro-3-(cyclopentyl(methyl)amino)benzoate (0.350 g, 61%).

المصدر