تفاعل #2295970

معادلة التفاعل

methyl 5-bromo-2-chloro-3-nitrobenzoate

ammonium chloride

→

methyl 3-amino-5-bromo-2-chlorobenzoate

المردود 92.1%

المذيبات

water

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحOn completion, the reaction mixture was filtered
2. 2
   غسيلthrough celite washing with ethanol and ethylacetate
3. 3
   استخلاصThe filtrate was extracted with ethyl acetate
4. 4
   غسيلthe combined organic layers were washed with water
5. 5
   أخرىdried
6. 6
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To stirred solution of methyl 5-bromo-2-chloro-3-nitrobenzoate (3.4 g, 11.6 mmol) in ethanol (19 mL) was added ammonium chloride (3.4 g, 57.8 mmol) dissolved in water (30 mL) and iron powder (5.16 g, 92.5 mmol). The reaction mixture was heated at 80° C. for 1 h. On completion, the reaction mixture was filtered through celite washing with ethanol and ethylacetate. The filtrate was extracted with ethyl acetate and the combined organic layers were washed with water, dried and concentrated under reduced pressure to give methyl 3-amino-5-bromo-2-chlorobenzoate (2.8 g, 92.1%).

المصدر