تفاعل #2293736

معادلة التفاعل

tert-butyl 2-methyl-1-(3-methylbutanoyl)-1H-indole-3-carboxylate

trifluoroacetic acid

→

title compound

المردود 89.0%

2-methyl-1-(3-methylbutanoyl)-1H-indole-3-carboxylic acid

المردود 89.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىThe mixture was evaporated
2. 2
   أخرىpartitioned between dichloromethane and water
3. 3
   غسيلThe aqueous layer was washed with dichloromethane (10 mL×2)
4. 4
   تجفيفdried over sodium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated in vacuum

الإجراء التجريبي

To a solution of tert-butyl 2-methyl-1-(3-methylbutanoyl)-1H-indole-3-carboxylate (200 mg, 634.10 μmol) in dichloromethane (5 mL) was added trifluoroacetic acid (5 mL). The mixture was stirred at room temperature (25° C.) for 1 hour. The mixture was evaporated and partitioned between dichloromethane and water. The aqueous layer was washed with dichloromethane (10 mL×2), combined the organic layers, dried over sodium sulfate, then filtered and concentrated in vacuum afford the title compound (30 mg, yield: 89%).

المصدر