تفاعل #2292798

معادلة التفاعل

Ethylmagnesium bromide

6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile

Sodium borohydride

→

title compound

المردود 81.0%

1-(6-Bromo-1-methyl-1H-pyrrolo[3,2-b]pyridin-5-yl)propan-1-amine

المردود 81.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىquenched with methanol (5 mL)
2. 2
   workup.STIRRINGThe reaction mixture was stirred for one hour
3. 3
   أخرىquenched with 1N HCl (1.5 mL)
4. 4
   workup.STIRRINGstirred for 20 minutes
5. 5
   استخلاصextracted with ethyl acetate (2×)
6. 6
   تجفيفThe organic layer was dried over anhydrous magnesium sulfate
7. 7
   تركيزconcentrated

الإجراء التجريبي

Ethylmagnesium bromide (4.18 mL, 12.54 mmol) was added to a stirred solution of 6-bromo-1-methyl-1H-pyrrolo[3,2-b]pyridine-5-carbonitrile (740 mg, 3.13 mmol) in THF (16 mL) at room temperature. The mixture was stirred for one hour at room temperature and then quenched with methanol (5 mL). Sodium borohydride (237 mg, 6.27 mmol) was added. The reaction mixture was stirred for one hour, quenched with 1N HCl (1.5 mL) and stirred for 20 minutes. Next, the mixture was basified with saturated aqueous sodium bicarbonate and extracted with ethyl acetate (2×). The organic layer was dried over anhydrous magnesium sulfate and concentrated to give the title compound as a tan oil (680 mg, 81%). ESI-MS m/z [M+H]+ calc'd for C11H14BrN3, 268. found 268.

المصدر