تفاعل #2286381

معادلة التفاعل

2-bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester

lithium hydroxide hydrate

hydrochloric acid

→

product

المردود 98.0%

2-bromo-4-methyl-thiazole-5-carboxylic acid

المردود 98.0%

المذيبات

water

ethyl acetate

tetrahydrofuran

water

ظروف التفاعل

المعالجة

1. 1
   استخلاصwas extracted with ethyl acetate
2. 2
   تجفيفThe organic extracts were dried over sodium sulfate (Na2SO4)
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated

الإجراء التجريبي

To a solution of 2-bromo-4-methyl-thiazole-5-carboxylic acid ethyl ester (3.0 g, 12 mmol) in tetrahydrofuran (THF, 50 mL) and water (5 mL) was added lithium hydroxide hydrate (1.0 g, 24 mmol). The reaction mixture was stirred at ambient temperature for 16 h. The reaction mixture was diluted with water and ethyl acetate. The aqueous layer was made acidic to pH 1 with 2 N hydrochloric acid (HCl) and then was extracted with ethyl acetate. The organic extracts were dried over sodium sulfate (Na2SO4), filtered and concentrated to provide product as an orange solid (2.6 g, 98%): mp 152-155° C.; 1H NMR (300 MHz, CDCl3) δ 2.74 (s, 3H); ESIMS m/z 221 (M−1).

المصدر