تفاعل #2286359

معادلة التفاعل

methoxyammonium chloride

tert-butyl 4-{4-[methoxy(methyl)carbamoyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate

ethanol

water

→

tert-Butyl 4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe aqueous phase was separated off
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   تجفيفThe combined organic phases were dried over sodium sulphate
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   أخرىThe residue was purified chromatographically

الإجراء التجريبي

At room temperature, methoxyammonium chloride (171 mg) was added to a solution of tert-butyl 4-{4-[methoxy(methyl)carbamoyl]-1,3-thiazol-2-yl}piperidine-1-carboxylate (403 mg) in ethanol (2 ml). The reaction mixture was stirred at 50° C. for 24 hours, and water was then added. The aqueous phase was separated off and extracted with ethyl acetate. The combined organic phases were dried over sodium sulphate and concentrated under reduced pressure. The residue was purified chromatographically. This gave tert-butyl 4-[4-(2-cyclohexyl-N-methoxyethanimidoyl)-1,3-thiazol-2-yl]piperidine-1-carboxylate (361 mg).

المصدر