تفاعل #2281691

معادلة التفاعل

sodium hydrogen carbonate

lithium hydroxide monohydrate

water

ethyl 1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate

→

title compound

المردود 89.7%

1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylic acid

المردود 89.7%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   غسيلthe mixture was washed with ethyl acetate
2. 2
   استخلاصthe mixture was extracted with ethyl acetate
3. 3
   غسيلThe organic phase was washed with water
4. 4
   أخرىdried
5. 5
   تركيزconcentrated
6. 6
   غسيلThe residue was washed with diisopropyl ether

الإجراء التجريبي

1.66 g (7.1 mmol) of ethyl 1-methyl-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate was dissolved in 1,4-dioxane (50 mL), and 0.45 g (11 mmol) of lithium hydroxide monohydrate and 10 mL of water were added to the solution at room temperature. The resulting mixture was stirred for 1.5 hours at room temperature. The reaction mixture was poured into an aqueous solution of sodium hydrogen carbonate, and the mixture was washed with ethyl acetate. The aqueous phase was acidified with citric acid, and then the mixture was extracted with ethyl acetate. The organic phase was washed with water, dried, and concentrated. The residue was washed with diisopropyl ether, and 1.30 g (yield: 89%) of the title compound was obtained as colorless crystals.

المصدر