تفاعل #2275740

ord-2c206cacea814afc96cc11131a343c08

معادلة التفاعل

O=C(CNC(=O)c1cccc(C(F)(F)F)c1)NC1CNC1
N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide
Cc1ccc(OC2CCC(=O)CC2)nc1
4-(5-methyl-pyridin-2-yloxy)-cyclohexanone
Cc1ccc(OC2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)nc1
title compounds
Cc1ccc(OC2CCC(N3CC(NC(=O)CNC(=O)c4cccc(C(F)(F)F)c4)C3)CC2)nc1
N-({1-[4-(5-Methyl-pyridin-2-yloxy)-cyclohexyl]-azetidin-3-ylcarbamoyl}-methyl)-3-trifluoromethyl-benzamide

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

The title compounds were prepared as white solids from the reductive amination of 4-(5-methyl-pyridin-2-yloxy)-cyclohexanone (as prepared in the previous step) and N-(azetidin-3-ylcarbamoylmethyl)-3-trifluoromethyl-benzamide (as prepared in Example 2 Step C) using the procedure described in Step D of Example 1.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US08324186B2uspto-grants-2012_12