تفاعل #2275727

معادلة التفاعل

1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one

HCl

sodium bicarbonate

→

title compound

1-(4-Oxo-cyclohexyl)-1H-pyridin-2-one

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed in vacuo and residue
2. 2
   أخرىpartitioned between ethyl acetate and water
3. 3
   غسيلThe organic layer was washed with brine
4. 4
   تجفيفdried over anhydrous Na2SO4
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated

الإجراء التجريبي

A solution of 1-(1,4-dioxa-spiro[4.5]dec-8-yl)-1H-pyridin-2-one (as prepared in the previous step, ˜300 mg, 1.28 mmol)) in acetone (10 mL) was treated with 1N HCl (2 mL) at room temperature for 4 hours. The reaction was worked up with saturated sodium bicarbonate to adjust the pH to neutral. The solvent was removed in vacuo and residue partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered, concentrated to afford the title compound as white solid.

المصدر