تفاعل #2275725

معادلة التفاعل

2-methyl-propane-2-sulfinic acid amide

1,4-dioxa-spiro[4.5]decan-8-one

dichloromethane

THF

→

2-methyl-propane-2-sulfinic acid (1,4-dioxa-spiro[4.5]dec-8-ylidene)-amide

المذيبات

dioxane

ظروف التفاعل

الإجراء التجريبي

Commercially available 2-methyl-propane-2-sulfinic acid amide is reacted with commercially available 1,4-dioxa-spiro[4.5]decan-8-one in the presence of a coupling agent such as Ti(OEt)4 or CuSO4, in an organic solvent such as dichloromethane, THF or dioxane, at a temperature in the range of about 25° C. to about 80° C., to yield 2-methyl-propane-2-sulfinic acid (1,4-dioxa-spiro[4.5]dec-8-ylidene)-amide. 2-Methyl-propane-2-sulfinic acid (1,4-dioxa-spiro[4.5]dec-8-ylidene)-amide is treated with an organometalic agent such as R1MgBr or R1Li, in an organic solvent such as ether, THF or dioxane, at a temperature in the range of about ˜78° C. to about 25° C., to yield the corresponding sulfonamide (XXVI).

المصدر