تفاعل #2275721

معادلة التفاعل

5-amino-1-(2,6-dichloro-4-(trifluoromethyl) phenyl)-4-((trifluoromethyl) sulfinyl)-1H-pyrazol-3-carbonitrile

hydrogen peroxide

water

→

pale yellow crystal

المردود 110.3%

5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfonyl)-1H-pyrazol-3-carbonitrile

المردود 110.3%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىreacted at 55° C. for 6 hours
2. 2
   درجة الحرارةThe reaction solution was cooled
3. 3
   استخلاصthe reaction mixture was extracted twice with 10 mL ethyl acetate
4. 4
   غسيلThe ethyl acetate layer was washed with water
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated

الإجراء التجريبي

0.17 g (0.4 mmol) of 5-amino-1-(2,6-dichloro-4-(trifluoromethyl) phenyl)-4-((trifluoromethyl) sulfinyl)-1H-pyrazol-3-carbonitrile, 0.01 g (0.03 mmol) of sodium tungstate.2H2O, and 0.07 g (0.6 mmol) of 30% aqueous hydrogen peroxide were dissolved in 1 mL acetic acid and reacted at 55° C. for 6 hours. The reaction solution was cooled, 10 mL water was added, and the reaction mixture was extracted twice with 10 mL ethyl acetate. The ethyl acetate layer was washed with water, then dehydrated over anhydrous magnesium sulfate, filtered and concentrated to give 0.2 g pale yellow crystal of 5-amino-1-(2,6-dichloro-4-(trifluoromethyl) phenyl)-4-((trifluoromethyl) sulfonyl)-1H-pyrazol-3-carbonitrile.

المصدر