تفاعل #2275698

معادلة التفاعل

[(3-hydroxy-5-trifluoromethane-sulfonyloxy-pyridine-2-carbonyl)-amino]-acetic acid methyl ester

3-chlorophenylboronic acid

K3PO4

→

desired compound

المردود 53.0%

{[5-(3-chloro-phenyl)-3-hydroxy-pyridine-2-carbonyl]-amino}-acetic acid methyl ester

المردود 53.0%

المذيبات

1,4-dioxane

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةAfter this time, the mixture is cooled to room temperature
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   workup.ADDITIONThe residue is then treated with 1M HCl (1 mL)
4. 4
   workup.ADDITIONdiluted with EtOAc
5. 5
   أخرىThe organic layer is separated
6. 6
   غسيلwashed with H2O, saturated aqueous NaCl
7. 7
   تركيزconcentrated under reduced pressure
8. 8
   أخرىThe crude material is purified over silica (EtOAc:heptane 3:7)
9. 9
   أخرىThe resulting solid can be crystallized from EtOAc/heptane

الإجراء التجريبي

To a degassed solution of [(3-hydroxy-5-trifluoromethane-sulfonyloxy-pyridine-2-carbonyl)-amino]-acetic acid methyl ester, 5, (0.30 g, 0.84 mmol) in 1,4-dioxane (10 mL) at room temperature under N2 is added 3-chlorophenylboronic acid (0.196 g, 1.26 mmol), Pd(dppf)Cl2 (0.068 g, 0.0084 mmol) and K3PO4 (0.195 g, 0.92 mmol). The resulting suspension is heated in a sealed tube at 85° C. for 16 hours. After this time, the mixture is cooled to room temperature and concentrated under reduced pressure. The residue is then treated with 1M HCl (1 mL) and diluted with EtOAc. The organic layer is separated, washed with H2O, saturated aqueous NaCl and concentrated under reduced pressure. The crude material is purified over silica (EtOAc:heptane 3:7). The resulting solid can be crystallized from EtOAc/heptane to afford 0.143 g (53% yield) of the desired compound as a colorless solid. 1H NMR (400 MHz, CDCl3) δ ppm 11.77 (1H, s), 8.36 (1H, t, J=5.7 Hz), 8.24 (1H, d, J=1.8 Hz), 7.50-7.53 (1H, m), 7.39-7.42 (2H, m), 7.34-7.37 (2H, m), 4.20 (2H, d, J=5.9 Hz), 3.76 (3H, s). HPLC-MS: m/z.

المصدر