تفاعل #2272

معادلة التفاعل

acetic acid

2-(4-chlorophenyl)-3-dimethylaminopropenal

sodium methoxide

cyanoacetamide

→

3-cyano-5-(4-chlorophenyl)-2-pyridinone

المذيبات

water

methanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe resulting suspension was refluxed overnight
2. 2
   أخرىDuring this time a yellow solid was formed
3. 3
   ترشيحThe resulting yellow orange solid was filtered off
4. 4
   غسيلwashed several times with water
5. 5
   أخرىdried

الإجراء التجريبي

To solution of sodium methoxide (7.52 g) in methanol (130 ml) was added cyanoacetamide (5.84 g) followed by 2-(4-chlorophenyl)-3-dimethylaminopropenal and the resulting suspension was refluxed overnight. During this time a yellow solid was formed. The mixture was cooled to room temperature and glacial acetic acid (50 ml) was added followed by water (100 ml). The resulting yellow orange solid was filtered off, washed several times with water and dried to yield 8.1 g of 3-cyano-5-(4-chlorophenyl)-2-pyridinone.

المصدر