تفاعل #2271913

معادلة التفاعل

methyl 3-[(2-aminoethylthio)methyl]-4-oxo-4-(3-pyridyl)butanoate

3-(acetylamino)propanoic acid

dicyclohexylcarbodiimide

1-hydroxybenzotriazole

N-methylmorpholine

→

title compound

المردود 75.0%

Methyl 3-({2-[3-(Acetylamino)propanoylamino]ethylthio}-methyl)-4-oxo-4-(3-pyridyl)butanoate

المردود 75.0%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   تركيزThe solution was concentrated
2. 2
   أخرىpurified by flash chromatography (SiO2, chloroform:methanol=9:1)

الإجراء التجريبي

A solution of methyl 3-[(2-aminoethylthio)methyl]-4-oxo-4-(3-pyridyl)butanoate (747 mg), 3-(acetylamino)propanoic acid (302 mg), dicyclohexylcarbodiimide (433 mg), 1-hydroxybenzotriazole (567 mg) and N-methylmorpholine (402 mg) in dichloromethane (10 mL) were stirred at room temperature overnight. The solution was concentrated and purified by flash chromatography (SiO2, chloroform:methanol=9:1) to give the title compound in 75% yield; ESMS (M+1)+353.

المصدر