تفاعل #2271682

معادلة التفاعل

6-fluoro-3-(4-piperdinyl)-1,2-benzisoxazole

K2CO3

3-chloropropoxybenzene

acetonitrile

→

6-fluoro-3-[1-(3-phenoxypropyl)-4-piperidinyl)-1,2-benzisoxazole

المردود 47.0%

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux under nitrogen for 30 hours
2. 2
   استخلاصthe aqueous mixture was extracted with ethyl acetate
3. 3
   استخلاصThe ethyl acetate extract
4. 4
   غسيلwas washed with brine
5. 5
   أخرىdried with MgS04
6. 6
   تركيزconcentrated
7. 7
   أخرىto afford 6.2 g of a damp, beige solid
8. 8
   أخرىThe compound was recrystallized twice from ethanol

الإجراء التجريبي

A mixture of 6-fluoro-3-(4-piperdinyl)-1,2-benzisoxazole (4.0 g, 18.2 mmol). K2CO3 (3.0 g, 21.8 mmol), Kl (100 mg), 3-chloropropoxybenzene (3.4 g, 20.0 mmol), and acetonitrile was stirred at reflux under nitrogen for 30 hours. The reaction was poured into water and the aqueous mixture was extracted with ethyl acetate. The ethyl acetate extract was washed with brine, dried with MgS04 and concentrated to afford 6.2 g of a damp, beige solid. The compound was recrystallized twice from ethanol to yield (47%) of 6-fluoro-3-[1-(3-phenoxypropyl)-4-piperidinyl)-1,2-benzisoxazole as a light beige solid, m.p.=78°-80° C.

المصدر