تفاعل #2268393

ord-d7bee7d3a8944a9896d4b33605eb829a

معادلة التفاعل

CCOC(=O)C(Cc1ccc2[nH]ccc2c1)OCC
rac-2-ethoxy-3-(1H-indol-5-yl)-propionic acid ethyl ester
Cc1oc(-c2ccc(F)cc2)nc1CCl
4-chloromethyl-2-(4-fluoro-phenyl)-5-methyl-oxazole
CCOC(Cc1ccc2c(ccn2Cc2nc(-c3ccc(F)cc3)oc2C)c1)C(=O)O
title compound
المردود 39.0%
CCOC(Cc1ccc2c(ccn2Cc2nc(-c3ccc(F)cc3)oc2C)c1)C(=O)O
Rac-2-Ethoxy-3-{1-[2-(4-fluoro-phenyl)-5-methyl-oxazol-4-ylmethyl]-1H-indol-5-yl}-propionic Acid
المردود 39.0%

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Starting from rac-2-ethoxy-3-(1H-indol-5-yl)-propionic acid ethyl ester and 4-chloromethyl-2-(4-fluoro-phenyl)-5-methyl-oxazole, the title compound was obtained in 39% yield as a colourless solid. MS: (M+H)30 423.3.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US06890947B2uspto-grants-2005_05