تفاعل #2267067

معادلة التفاعل

3-methoxyphenylacetone

NaBH4

→

desired product 2

المردود 100.0%

1-(3-Methoxyphenyl)-2-propyl alcohol

المردود 100.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   استخلاصIt was extracted with CHCl3 three times
2. 2
   غسيلThe combined organic phase was washed with brine
3. 3
   تجفيفdried over Na2SO4
4. 4
   أخرىRemoval of the solvent
5. 5
   أخرىafforded the crude product
6. 6
   أخرىPurification of the crude product

الإجراء التجريبي

To a solution of 3-methoxyphenylacetone (1, 1.0 g) in methanol (30 ml) was added NaBH4 (360 mg) in portions in the period of 20 min at 0° C. The resulting solution was stirred at such temperature for another 40 min. No more starting materials were detected from TLC. Ice water was added to the reaction slowly. It was extracted with CHCl3 three times. The combined organic phase was washed with brine, and dried over Na2SO4. Removal of the solvent afforded the crude product. Purification of the crude product by using a silica gel column gave the desired product 2 (1.01 g, 100%).

المصدر