تفاعل #2266936

معادلة التفاعل

1-tert-butyl 4-ethyl 4-ethylpiperidine-1,4-dicarboxylate

trifluoro acetic acid

NaHCO3

→

title compound

المردود 95.8%

ethyl 4-ethylpiperidine-4-carboxylate

المردود 95.8%

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction at room temperature for about 6 hours
2. 2
   أخرىUpon completion of the reaction (monitored by TLC)
3. 3
   استخلاصextracted with DCM
4. 4
   تجفيفthe organic layer was dried over Na2SO4
5. 5
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To a stirred solution of 1-tert-butyl 4-ethyl 4-ethylpiperidine-1,4-dicarboxylate (above step 2, 4.5 g, 12.96 mmol) in 50 ml DCM was cooled to 0° C. After ten minutes trifluoro acetic acid (6.0 g) was added and stirred the reaction at room temperature for about 6 hours. Upon completion of the reaction (monitored by TLC), the reaction mixture was neutralized with saturated NaHCO3 and extracted with DCM, the organic layer was dried over Na2SO4 and concentrated under reduced pressure to furnish the title compound (2.3 g) as a light yellow liquid. 1H NMR (300 MHz, CDCl3): 1.19-1.24 (t, 3H); 1.48-1.58 (m, 2H); 2.14-2.18 (m, 2H); 2.64-2.73 (m, 2H); 2.86 (s, 2H); 3.01-3.07 (m, 4H); 4.10-4.17 (m, 2H); 7.07-7.10 (m, 2H); 7.24-7.30 (m, 3H); ES Mass: 186 (100%), [M+1].

المصدر