تفاعل #2263920

ord-222d4715782f40a688aa4ed77c3f048c

معادلة التفاعل

COC(=O)N1CC[C@H]2[C@@H]1CCC[C@]2(O)C#Cc1cccc(C)c1
(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester
COCCOCC(=O)O
(2-methoxy-ethoxy)-acetic acid
→
COCCOCC(=O)O[C@@]1(C#Cc2cccc(C)c2)CCC[C@@H]2[C@H]1CCN2C(=O)OC
(3aR,4S,7aR)-4-[2-(2-methoxy-ethoxy)-acetoxy]-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester

المتفاعلات

COC(=O)N1CC[C@H]2[C@@H]1CCC[C@]2(O)C#Cc1cccc(C)c1
(3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester
COCCOCC(=O)O
(2-methoxy-ethoxy)-acetic acid

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

Synthesis in analogy to the General Method 1 starting from (3aS,4R,7aS)-4-hydroxy-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester and (2-methoxy-ethoxy)-acetic acid to yield (3aR,4S,7aR)-4-[2-(2-methoxy-ethoxy)-acetoxy]-4-m-tolylethynyl-octahydro-indole-1-carboxylic acid methyl ester. MS [M+H] 430; RT=7.850 min; HPLC Method I

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US09067881B2uspto-grants-2015_06