تفاعل #2254239

معادلة التفاعل

methyl thioglycolate

triphenylmethanol

hexane

→

Triphenylmethyl thioglycolic acid methyl ester

المردود 97.5%

المذيبات

trichloromethane

chloroform

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction
2. 2
   غسيلwash the reaction solution with water (2×100 mL)
3. 3
   تجفيفThe organic phase is dried by anhydrous sodium sulfate
4. 4
   أخرىthe solvent is removed by vacuum evaporation

الإجراء التجريبي

Dissolve 5.0 mL (55.0 mmol) methyl thioglycolate and 14.3 g (55.0 mmol) triphenylmethanol in 80 mL trichloromethane. Then slowly drop 6.9 mL (55.0 mmol) boron trifluoride ethyl ether complex into the solution and stir the solution at room temperature. Use thin layer chromatography (TLC)(chloroform:hexane=1:1) to follow the reaction. After starting material disappeared completely, wash the reaction solution with water (2×100 mL). The organic phase is dried by anhydrous sodium sulfate and then the solvent is removed by vacuum evaporation to get 18.6 g (97.5%) Triphenylmethyl thioglycolic acid methyl ester.

المصدر