تفاعل #2254228

معادلة التفاعل

potassium carbonate

dimethoxy acetaldehyde

diethyl ether

→

desired compound

المردود 90.0%

4,4-Dimethoxy-but-2-enoic acid ethyl ester

المردود 90.0%

المذيبات

tetrahydrofuran

water

ظروف التفاعل

المعالجة

1. 1
   غسيلwash with saturated aqueous sodium chloride
2. 2
   تجفيفDry the organic phase over sodium sulfate
3. 3
   تركيزconcentrate under reduced pressure

الإجراء التجريبي

Add potassium carbonate (16.5 g, 120 mmol) to a solution of dimethoxy acetaldehyde (60% wt. in water) (15 mL, 100 mmol) and triethyl phosphonoacetate (20 mL, 100 mmol) in 210 mL tetrahydrofuran and 30 mL water. Stir the mixture at room temperature for 4 hours. Pour the reaction mixture into diethyl ether (200 mL) and wash with saturated aqueous sodium chloride. Dry the organic phase over sodium sulfate and concentrate under reduced pressure to provide the desired compound as a yellow oil (15.8 g, 90%).

المصدر