تفاعل #2254209

معادلة التفاعل

sodium triacetoxyborohydride

2-[2,2-dimethyl-4-(4-methylphenyl)oxan-4-yl]acetaldehyde

3-methylbenzylamine

acetic acid

→

{2-[2,2-dimethyl-4-(4-methylphenyl)oxan-4-yl]ethyl}[(3-methylphenyl)methyl]amine

المذيبات

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGThe resulting mixture was stirred at rt for 18 h
2. 2
   تركيزThe mix was concentrated
3. 3
   workup.DISSOLUTIONdissolved in MeOH
4. 4
   أخرىpurified by HPLC

الإجراء التجريبي

A mixture of 2-[2,2-dimethyl-4-(4-methylphenyl)oxan-4-yl]acetaldehyde (61.6 mg, 0.25 mmol), 3-methylbenzylamine (63 μl, 0.5 mmol) and acetic acid (50 μl, 8.6 mmol) in CH2Cl2 (3 ml) was stirred at rt for 1 h before it adding sodium triacetoxyborohydride (106 mg, 0.50 mmol). The resulting mixture was stirred at rt for 18 h. The mix was concentrated and dissolved in MeOH and purified by HPLC to give {2-[2,2-dimethyl-4-(4-methylphenyl)oxan-4-yl]ethyl}[(3-methylphenyl)methyl]amine as a white solid (35 mg, 40%, m/z: 352.3 [M+H]+ observed).

المصدر