تفاعل #2252113

معادلة التفاعل

potassium carbonate

potassium iodide

potassium carbonate

potassium iodide

(4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid ethyl ester

bis(2-chloroethyl)ether

potassium carbonate

→

[4-acetyl-3-[2-(2-chloroethoxy)ethoxy]-2-propylphenoxy]acetic acid ethyl ester

المردود 72.0%

المذيبات

dimethylformamide

acetone

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux
2. 2
   درجة الحرارةreflux
3. 3
   workup.WAITAfter 50 hours
4. 4
   تركيزAfter a total reflux time of 108 hours, the reaction mixture was concentrated in vacuo
5. 5
   أخرىthe residue was purified by high pressure liquid chromatography

الإجراء التجريبي

A mixture of 6.0 g of (4-acetyl-3-hydroxy-2-propylphenoxy)acetic acid ethyl ester, 25 ml of bis(2-chloroethyl)ether and 2.2 g of anhydrous potassium carbonate in 150 ml of anhydrous acetone was stirred at reflux. After 24 hours, 2 g of potassium iodide and 50 ml of anhydrous dimethylformamide were added and reflux was continued. After 50 hours, 2.2 g of potassium carbonate and 2 g of potassium iodide were added and after 77 hours, 2.0 g of potassium carbonate was added. After a total reflux time of 108 hours, the reaction mixture was concentrated in vacuo and the residue was purified by high pressure liquid chromatography using 25% ethyl acetate-hexane to give 5.96 g (72% yield) of [4-acetyl-3-[2-(2-chloroethoxy)ethoxy]-2-propylphenoxy]acetic acid ethyl ester as an oil.

المصدر