تفاعل #2252
ord-80c466f42a2f4da1817b28cc4a125e1c
معادلة التفاعل
3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one
3-trifluoromethylphenyl-guanidine nitrate
sodium hydroxide
→
N-(3-trifluoromethyl-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine
المتفاعلات
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1ترشيحfiltered
- 2غسيلis washed with 2-propanol and water
- 3أخرىdried at 50° under HV
الإجراء التجريبي
150 mg (0.71 mmol) of 3-dimethylamino-1-(2-chloro-4-pyridyl)-2-propen-1-one are suspended in 1.5 ml of 2-propanol. 190 mg (0.712 mmol) of 3-trifluoromethylphenyl-guanidine nitrate and 31 mg (0.783 mmol) of sodium hydroxide are added and the reaction mixture is stirred for 18 h under RF. It is then cooled to RT and filtered, and the material retained on the filter is washed with 2-propanol and water and dried at 50° under HV to give N-(3-trifluoromethyl-phenyl)-4-(2-chloro-4-pyridyl)-2-pyrimidineamine;