تفاعل #2251229

معادلة التفاعل

water

4-carboxy-1-ethoxyisoquinoline

potassium nitrate

→

4-carboxy-1-ethoxy-5-nitroisoquinoline

المردود 100.7%

المذيبات

sulphuric acid

sulphuric acid

ظروف التفاعل

المعالجة

1. 1
   أخرىthe temperature below 20° C
2. 2
   workup.ADDITIONthe reaction solution is then poured
3. 3
   ترشيحThe fine yellow crystals which precipitate are filtered off
4. 4
   غسيلwashed with water until a neutral filtrate
5. 5
   أخرىis obtained
6. 6
   أخرىAfter drying

الإجراء التجريبي

A solution of potassium nitrate (34.9 g) in sulphuric acid (density 1.83; 280 cc) is added dropwise to a solution, stirred and cooled by iced water, of 4-carboxy-1-ethoxyisoquinoline (69.5 g) in sulphuric acid (density 1.83; 420 cc), whilst keeping the temperature below 20° C. The reactants are kept in contact for 16 hours at a temperature of about 20° C. and the reaction solution is then poured onto crushed ice (7 kg). The fine yellow crystals which precipitate are filtered off and then washed with water until a neutral filtrate is obtained. After drying, crude 4-carboxy-1-ethoxy-5-nitroisoquinoline (84.5 g) is obtained.

المصدر