تفاعل #2245

معادلة التفاعل

3-(4-pyridinylamino)-1,2-benzisoxazole

methyl bromoacetate

→

title compound

المردود 70.0%

[4-(3-Benzo[d]isoxazolylimino)-1-(4H)-pyridinyl]-acetic acid methyl ester hydrobromide

المردود 70.0%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for one hour
3. 3
   ترشيحthe precipitated product was collected by filtration
4. 4
   غسيلThe white solid was washed with diethyl ether
5. 5
   أخرىdried under vacuum

الإجراء التجريبي

A mixture of 3-(4-pyridinylamino)-1,2-benzisoxazole (0.9 g, 4.3 mmol) and methyl bromoacetate (0.44 mL, 1.1 eq) in acetonitrile (25 mL) was heated at reflux for one hour. The mixture was then allowed to cool to room temperature and the precipitated product was collected by filtration. The white solid was washed with diethyl ether and dried under vacuum to provide the title compound (1.1 g, 70%), mp 235-236° C.

المصدر