تفاعل #220490

معادلة التفاعل

iso-butanol

pyridine

2-bromopropionyl bromide

→

title compound

Iso-butyl 2-bromopropionate

المذيبات

diethyl ether

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with 1N HCl, water, aqueous NaHCO3, brine
2. 2
   تجفيفdried over magnesium sulfate or sodium sulfate
3. 3
   أخرىRemoval of the solvents at reduced pressure

الإجراء التجريبي

To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.

المصدر