تفاعل #220314

معادلة التفاعل

tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-yl]carbamate

Intermediate 7

tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-yl]carbamate

2-amino-1-[1-(trifluoromethyl)cyclopropyl]ethanol

→

title compound

tert-Butyl[(2Z,3R,6S)-6-(2,3-difluorophenyl)-2-({2-hydroxy-2-[1-(trifluoromethyl)cyclopropyl]ethyl}imino)azepan-3-yl]carbamate

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   تركيزconcentrated under reduced pressure
3. 3
   workup.ADDITIONSaturated aqueous NaHCO3 was added
4. 4
   استخلاصthe mixture was extracted with CH2Cl2 (3×)
5. 5
   تجفيفThe combined organic extracts were dried over MgSO4
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

Mercury(II) chloride (149 mg, 0.547 mmol) was added to a solution of tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-thioxoazepan-3-yl]carbamate (150 mg, 0.421 mmol, described in Intermediate 7), and 2-amino-1-[1-(trifluoromethyl)cyclopropyl]ethanol (569 mg, 3.367 mmol) in ethanol (5 mL) at 60° C. After 10 min, the reaction was allowed to cool to ambient temperature. The mixture was filtered and concentrated under reduced pressure. Saturated aqueous NaHCO3 was added and the mixture was extracted with CH2Cl2 (3×). The combined organic extracts were dried over MgSO4, filtered, and concentrated under reduced pressure to give the title compound. MS: m/z=492 (M+1).

المصدر