تفاعل #2200634

معادلة التفاعل

5-fluoro-2-(4-methyl-imidazol-1-yl)-benzonitrile

Eschenmoser's salt

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title compound

المردود 34.0%

2-(5-Dimethylaminomethyl-4-methyl-imidazol-1-yl)-5-fluoro-benzonitrile

المردود 34.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of the solvent, aqueous workup and crystallization from Ethyl acetate/diisopropylether

الإجراء التجريبي

In analogy to example 5b, 5-fluoro-2-(4-methyl-imidazol-1-yl)-benzonitrile was reacted with Eschenmoser's salt in DMF for 24 h at 90° C. Evaporation of the solvent, aqueous workup and crystallization from Ethyl acetate/diisopropylether afforded the title compound as a white solid (yield: 34%). MS: m/e=259.2 [M+H]+.

المصدر