تفاعل #2200633

معادلة التفاعل

2,5-difluoro-benzonitrile

4-methylimidazole

potassium carbonate

→

solid

المردود 41.0%

5-Fluoro-2-(4-methyl-imidazol-1-yl)-benzonitrile

المردود 41.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter aqueous workup and crystallization from Ethyl acetate the title compound

الإجراء التجريبي

In analogy to example 5a, 2,5-difluoro-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 20 h at 90° C. After aqueous workup and crystallization from Ethyl acetate the title compound was obtained as a white solid (yield: 41%). MS: m/e=202.3 [M+H]+.

المصدر