تفاعل #2200632
ord-386e2d333884458d94b5dc6865bb9298
معادلة التفاعل
5-chloro-2-(4-methyl-imidazol-1-yl)-benzonitrile
Eschenmoser's salt
→
title compound
المردود 17.0%
5-Chloro-2-(5-dimethylaminomethyl-4-methyl-imidazol-1-yl)-benzonitrile
المردود 17.0%
الكواشف
لا شيء
المذيبات
ظروف التفاعل
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1أخرىEvaporation of the solvent, aqueous workup and crystallization from Ethyl acetate
الإجراء التجريبي
In analogy to example 5b, 5-chloro-2-(4-methyl-imidazol-1-yl)-benzonitrile was reacted with Eschenmoser's salt in DMF for 16 h at 90° C. Evaporation of the solvent, aqueous workup and crystallization from Ethyl acetate afforded the title compound as a white solid (yield: 17%). MS: m/e=275.1 [M+H]+.