تفاعل #2200630

معادلة التفاعل

5-trifluoromethoxy-2-(4-methyl-imidazol-1-yl)-benzonitrile

Eschenmoser's salt

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title compound

المردود 38.0%

2-(5-Dimethylaminomethyl-4-methyl-imidazol-1-yl)-5-trifluoromethoxy-benzonitrile

المردود 38.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of the solvent, aqueous workup and chromatography

الإجراء التجريبي

In analogy to example 5b, 5-trifluoromethoxy-2-(4-methyl-imidazol-1-yl)-benzonitrile (+regioisomer) was reacted with Eschenmoser's salt in DMF for 24 h at 90° C. Evaporation of the solvent, aqueous workup and chromatography afforded the title compound as a colorless oil that was sufficiently pure to be used in the next step (yield: 38%). 1H-NMR (300 MHz, DMSO): δ=1.93 (s, 6H), 2.17 (s, 3H), 3.21 (s, 2H), 7.80-7.95 (m, 3H), 8.22 (s, 1H).

المصدر