تفاعل #2200626

معادلة التفاعل

dry ice

Tert.-butyllithium

1-fluoro-4-trifluoromethoxy-benzene

DMF

→

title compound

المردود 53.0%

2-Fluoro-5-trifluoromethoxy-benzaldehyde

المردود 53.0%

المذيبات

pentane

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىwas kept <−70° C
2. 2
   أخرىtemperature <−70° C
3. 3
   workup.WAITAfter 30 min the reaction mixture was allowed
4. 4
   أخرىto reach rt
5. 5
   أخرىquenched with saturated NH4Cl solution
6. 6
   استخلاصextracted with ether
7. 7
   غسيلThe organic phase was washed with brine
8. 8
   تركيزconcentrated
9. 9
   أخرىchromatographed (SiO2, heptane:ethyl acetate=100:0 to 80:2)

الإجراء التجريبي

A solution of 1-fluoro-4-trifluoromethoxy-benzene (21.0 g, 117 mmol) in THF (233 ml) was cooled to <−70° C. Tert.-butyllithium (86 ml of a 1.5 molar solution in pentane, 129 mmol) was added at such a rate that temperature was kept <−70° C. Stirring in the dry ice bath was continued for 15 min, then DMF (11.6 ml, 150 mmol) was added dropwise keeping temperature <−70° C. After 30 min the reaction mixture was allowed to reach rt, quenched with saturated NH4Cl solution and extracted with ether. The organic phase was washed with brine, concentrated and chromatographed (SiO2, heptane:ethyl acetate=100:0 to 80:2). The title compound (11.0 g, 53%) was obtained as a light yellow oil. 1H-NMR (300 MHz, DMSO): δ=7.60 (t, J=9.2 Hz, 1H), 7.75-7.85 (m, 2H), 10.20 (s, 1H).

المصدر