تفاعل #2200625

معادلة التفاعل

2-(4-methyl-imidazol-1-yl)-5-nitro-benzonitrile

Eschenmoser's salt

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title compound

المردود 35.0%

2-(5-Dimethylaminomethyl-4-methyl-imidazol-1-yl)-5-nitro-benzonitrile

المردود 35.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of the solvent, aqueous workup and chromatography

الإجراء التجريبي

In analogy to example 5b, 2-(4-methyl-imidazol-1-yl)-5-nitro-benzonitrile (+regioisomer) was reacted with Eschenmoser's salt in DMF for 16 h at 90° C. Evaporation of the solvent, aqueous workup and chromatography afforded the title compound as a yellow oil that was sufficiently pure to be used in the next step (yield: 35%). MS: m/e=286.1 [M+H]+.

المصدر