تفاعل #2200624

معادلة التفاعل

2-(5-methyl-imidazol-1-yl)-5-nitro-benzonitrile

2-fluoro-5-nitro-benzonitrile

4-methylimidazole

potassium carbonate

→

title compound

2-(4-Methyl-imidazol-1-yl)-5-nitro-benzonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىAqueous workup afforded

الإجراء التجريبي

In analogy to example 5a, 2-fluoro-5-nitro-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 1 h at 20° C. Aqueous workup afforded a 3.6:1 mixture of the title compound and its regioisomer [2-(5-methyl-imidazol-1-yl)-5-nitro-benzonitrile] as a light brown solid (yield: 69%). MS: m/e=229.4 [M+H]+.

المصدر