تفاعل #2200623

معادلة التفاعل

5-trifluoromethyl-2-(4-methyl-imidazol-1-yl)-benzonitrile

Eschenmoser's salt

→

title compound

المردود 53.0%

5-Trifluoromethyl-2-(5-dimethylaminomethyl-4-methyl-imidazol-1-yl)-benzonitrile

المردود 53.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىEvaporation of the solvent, aqueous workup and chromatography

الإجراء التجريبي

In analogy to example 5b, 5-trifluoromethyl-2-(4-methyl-imidazol-1-yl)-benzonitrile (+regioisomer) was reacted with Eschenmoser's salt in DMF for 16 h at 90° C. Evaporation of the solvent, aqueous workup and chromatography afforded the title compound as a yellow oil that was sufficiently pure to be used in the next step (yield: 53%). MS: m/e=309.3 [M+H]+.

المصدر