تفاعل #2200618

ord-048c501b647b414bb21489163d0f40be

معادلة التفاعل

Cc1ccc(F)c(C#N)c1
2-fluoro-5-methyl-benzonitrile
Cc1c[nH]cn1
4-methylimidazole
O=C([O-])[O-].[K+].[K+]
potassium carbonate
Cc1ccc(-n2cnc(C)c2)c(C#N)c1
title compound
Cc1ccc(-n2cnc(C)c2)c(C#N)c1
5-Methyl-2-(4-methyl-imidazol-1-yl)-benzonitrile

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

In analogy to example 5a, 2-fluoro-5-methyl-benzonitrile was reacted with 4-methylimidazole and potassium carbonate for 16 h at 90° C. After aqueous workup the title compound was obtained as a white solid (yield: 48%). MS: m/e=198.4 [M+H]+.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07432256B2uspto-grants-2008_10