تفاعل #2200604

معادلة التفاعل

2-chloro-1-phenylethanol

4,5-dimethylthiazole

→

product

3-(2-Phenyl-2-hydroxyethyl)-4,5-dimethylthiazolium chloride

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwere heated
2. 2
   درجة الحرارةIt was cooled to room temperature
3. 3
   workup.STIRRINGwith stirring
4. 4
   استخلاصwas extracted with ether (30 mL)
5. 5
   workup.ADDITIONThe water layer was treated with actived carbon
6. 6
   أخرىevaporated to dryness
7. 7
   أخرىIt was crystallized from a mixture of acetonitrile and ether

الإجراء التجريبي

The neat mixture of 2-chloro-1-phenylethanol (2.34 g, 14.9 mmol) and 4,5-dimethylthiazole (1.69 g, 14.9 mmol) were heated with stirring at 135° C. for 28 hrs. It was cooled to room temperature and water (30 mL) was added to the reaction mixture with stirring, and then was extracted with ether (30 mL). The water layer was treated with actived carbon and evaporated to dryness. It was crystallized from a mixture of acetonitrile and ether to give a racemic product as prisms; 0.39 g (9.7%); mp. 201-203° C.

المصدر