تفاعل #2200591

ord-1fff50506c2a4a5d944f955940948bea

معادلة التفاعل

O=C(O)C(=O)Cc1ccccc1
phenylpyruvic acid
CC(=O)C(=O)O
pyruvic acid
O=C(O)C(=O)CC(O)(Cc1ccccc1)C(=O)O
4-phenylmethyl-4-hydroxy-2-oxoglutaric acid

المتفاعلات

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

According to the study by the present inventors, it has been found that PtALD can catalyze the aldol condensation reaction of indolepyruvic acid with pyruvic acid (or oxalacetic acid) to yield 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid (IHOG), and the reaction of phenylpyruvic acid with pyruvic acid to yield 4-phenylmethyl-4-hydroxy-2-oxoglutaric acid (PHOG).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07432100B2uspto-grants-2008_10